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Scientific Lectures //

Novel Biomarkers of Vascular Brain Injury

Charles DeCarli, MD, FAAN, Victor and Genevieve Orsi Chair in Alzheimer's Research, Professor of Neurology, Director, Alzheimer's Disease Center and Imaging of Dementia and Aging (IDeA) Laboratory , Department of Neurology and Center for Neuroscience, University of California at Davis

Presented: December 8, 2017 

ABSTRACT: Small vessel cerebrovascular disease and Alzheimer's disease are the two most common causes of cognitive decline in the elderly, but methods for determining the relative contributions of both these pathologies to impairment, understanding their interactions, predicting progression and defining targets for clinical trials remain underdeveloped. This presentation will address work done at UC Davis to  further develop novel neuroimaging biomarkers of cerebrovascular disease, along with presentation of hypothetical “biomechanical” model of small vessel cerebrovascular disease.  Taken together, we hope our work will improve early detection of subclinical small vessel cerebrovascular disease in older subjects, possibly providing better targets and outcome metrics for clinical trials.

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