Scientific Lectures //
Cell Adhesion Molecule Barcodes, the Connectome, Addiction Vulnerability and Addiction Therapeutics
George Uhl, M.D., Ph.D.- Associate Chief of Staff/Research & Development, New Mexico VA Healthcare System
Presented: July 10, 2015
ABSTRACT: GWAS and other data now suggest that connectome differences that contribute to many complex brain disorders arise from individual differences in genes that encode cell adhesion molecules (CAMs).
Dr. Uhl will review CAMs, addiction-related CAM GWAS signals, human and mouse data that support significant roles for variation in CAM genes in brain connections that contribute to addiction vulnerability, paths toward small molecule ligands to modulate CAMs and implications for brain imaging and connectivity.