Scientific Lectures //
Arterial Spin Labeled Perfusion MRI in Cerebral Small Vessel Disease
Danny J.J. Wang, Ph.D., M.S.C.E., Professor of Neurology, Laboratory of FMRI Techology (LOFT), Director of Imaging Technology Innovation, Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California (USC)
Presented: October 5, 2017
ABSTRACT: Arterial spin labeling (ASL) is a noninvasive MRI technique to measure cerebral blood flow (CBF) using magnetically labeled arterial blood water as an endogenous tracer. ASL may offer a valuable imaging marker of cerebrovascular disorders and cerebral small vessel disease through noninvasive assessment of microvascular flow and other functions. In this talk, I will introduce recent technical advances of ASL, including several emerging ASL techniques for mapping microvascular perfusion, arterial stiffness or vascular compliance (VC) of small arteries/arterioles, and water exchange rate across the blood-brain barrier (BBB). I will also introduce a novel high-resolution black blood MRI for direct imaging of lenticulostriate perforating arteries. Finally, I will present a new direction to map functional connectivity of brain networks based on ASL CBF.