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COBRE Phase 2 //

Overview - Multimodal Imaging of Neuropsychiatry Disorders (MIND)


Phase II COBRE is a natural extension of phase I COBRE project in Schizophrenia. Multimodal imaging techniques are used in COBRE II to study the neuromechanisms of psychosis and mood disorders. The Phase II COBRE will provide support to five outstanding junior investigators through the assistance of strong senior mentors. The five projects each focus on distinct, but related, aspects of psychosis and mood disorders.




Phase II COBRE will have four cores:

  1. Administrative, Clinical Assessment and Mentoring (ACAM, previously ACAS)
  2. Multimodal Data Acquisition (MDA, previous IDA)
  3. Algorithm and Data Analysis (ADA, previously IA)
  4. Biostatistics and Neuroinformatics (BNI, previously STATNI)
Relationship between Cores and Projects

Analytic Relationship between the cores

The five projects and four cores will be located at the MIND Research Network (MRN) in Pete and Nancy Domenici Hall. Dr. Vince Calhoun will serve as the principal investigator (PI) of this COBRE. Integration between MRN and UNM is achieved by Dr. Calhoun holding dual roles as an MRN PI and a tenured UNM Professor with appointments in the Electrical and Computer Engineering, Psychiatry, Neurosciences, and Computer Science Departments.


MRN houses outstanding imaging resources that will be used to support this COBRE: a 306 channel Elekta Neuromag MEG System, a state-of-the-art high density electroencephalography [EEG] lab, an in-house 3T Siemens Trio scanner, and a mobile research 1.5T Siemens scanner. MRN will also provide data processing and management support to the project investigators through a centralized neuroinformatics system, a strong IT management plan, and state-of-the-art image analysis tools. Administrative leadership will be provided by regular meetings between the COBRE PI, the project PIs, the core directors, and the senior mentors. We intend to expand our powerful thematic interdisciplinary center by employing the expertise of senior investigators from Phase I cores. This multidisciplinary team of experts, with MRN’s unique tools at their disposal, will apply their four years of experience from Phase I to examine the neural mechanisms of multiple neuropsychiatric disorders and their treatment using a data-driven approach.


The specific aims for this COBRE fall into two broad groups: Scientific and Administrative.

Organizational Chart for COBRE Phase II

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