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Associate Professor of Translational Neuroscience
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 Dr. Caprihan is interested in multivariate statistical methods applied to understanding neuroimaging data from different modalities.
He is an MRI Physicist with interests in diffusion measurement by MRI and analysis of white matter structure in relation to brain function measured by fMRI and results of cognitive and psychological tests in patients with schizophrenia and psychopathy.
Education
• B. S., Electrical Engineering, Indian Institute of Technology, Bombay
• M. S., Electrical Engineering, Rice University
• Ph.D., Electrical Engineering, Rice University
Positions
• 1971 1972 Research Associate, Rice University, Houston, TX
• 1972 1979 Professor, Biomedical Engineering Department, COPPE/UFRJ, Rio de Janeiro, Brazil
• 1979 1980 Associate Scientist, Research Division, Lovelace Medical Foundation, Albuquerque, NM
• 1981 1982 Professor, Biomedical Engineering Department, COPPE/UFRJ, Rio de Janeiro, Brazil
• 1982 1997 Scientist, The Lovelace Institutes, Albuquerque, NM
• 1997 - 2007 Scientist, New Mexico Resonance, Albuquerque, NM
• 2002 - 2003 Research Scientist, The Mind Research Network, Albuquerque, NM
• 2007 – Present Scientist, The Mind Research Network, Albuquerque, NM
Other Experience and Professional Memberships
• 1971 - Present IEEE
• 1986 - Present ISMRM
Patent
• U.S. Patent 4,621,234 "Pulsed NMR Flow Measurement"
Selected Peer-Reviewed Publications
1. Caprihan A, Davis J, Altobelli SA and Fukushima E. A new method for flow velocity measurement: frequency encoded NMR. Mag. Reson. Med., 3:35262, 1986.
2. Majors PD, Blackley JL, Altobelli SA, Caprihan A and Fukushima E. “Eddy current compensation by direct field detection and digital gradient modification”. J. Magn. Reson., 87:548-53, 1990.
3. Caprihan A, Griffey RH and Fukushima E. “Velocity imaging of slow coherent flows using stimulated echoes”. Mag. Reson. Med., 15:317-333, 1990.
4. Caprihan A, Altobelli SA and Benitez-Read E. “Flow velocity imaging from linear regression of phase images with techniques for reducing eddy current effects”. J. of Magnet Resonance, 90:71-89, 1990.
5. Caprihan A and Fukushima E. “Flow measurements by NMR”. Physics Reports, 198:195-235, 1990.
6. Icenogle MV, Caprihan A and Fukushima, E. “Mapping flow streamlines by multistripe tagging”. J. Magn. Reson., 100:376-381, 1992.
7. Caprihan A and Icenogle MV. “A weighted least-squares method for Nuclear Magnetic Resonance velocity imaging”. Magn. Reson. Med., 29:512-520, 1993.
8. Vidal Melo MF, Loepkky JA, Caprihan A and Luft UC. “Alveolar ventilation to perfusion heterogeneity and diffusion impairment in a mathematical model of gas exchange”. Comp. Biom. Res., 26:103-120, 1993.
9. Nakagawa M, Altobelli SA, Caprihan A, Fukushima E and Jeong E-K. “Non- invasive measurements of granular flow by magnetic resonance imaging”. Experiments in Fluids, 16:54-60, 1993.
10. Wang LZ, Caprihan A and Fukushima E. “The narrow pulse criterion for pulsed gradient spin echo diffusion measurements”. J. Magn. Reson., A117:209-219, 1995.
11. Cheng HA, Robergs RA, Letellier JP, Caprihan A, Icenogle MV, Haseler LJ. “Changes in muscle proton relaxation and acidosis during incremental exercise and recovery”. J. Appl. Physiol., 79:1370-1378, 1995.
12. Caprihan, A, Wang, LZ and E. Fukushima, E, “A multiple narrow pulse approximation for restricted diffusion in a time varying field-gradient,” J. Magn. Reson. A, 1996; 118: 94-102.
13. Hill, KM, Caprihan, A and Kakalios, J, “Bulk Segregation in Rotated Granular Materials Measured by Magnetic Resonance Imaging,” Phys. Rev. Letters 78: 50-53, 1997.
14. Kose, K, Haishi, T, Caprihan, A, Fukushima, E, “Real-Time NMR Imaging Systems Using Personal Computers,” J. Magn. Reson., 1997; 124: 35-41.
15. Nakagawa, M, Altobelli, SA, Caprihan, A, and Fukushima, E, “NMR measurement and approximate derivation of the velocity depth-profile of granular flow in a rotating, partially filled, horizontal cylinder,” in Powders and Grains 97, Proceedings of the Third International Conference on Powders & Grains, edited by R. P. Behringer and J. T. Jenkins (A. A. Balkema, Rotterdam, 1997); pp. 447-450.
16. Caprihan, A, Fukushima, E, Rosato, AD, and Kos, M, "Magnetic Resonance Imaging of Vibrating Granular Beds by Spatial Imaging," Rev. Sci. Instrum., 1997; 68:4217-4220.
17. Hill, KM, Caprihan, A, and Kakalios, J, “Axial segregation of granular media rotated in a drum mixer: Pattern evolution,” Phys. Rev. E, 1997; 56:4386-4393.
18. Nakagawa, M, Altobelli, SA, Caprihan, A, and Fukushima, E, “An MRI study: Axial migration of radially segregated core of granular mixture in a horizontal rotating cylinder,” Chemical Engineering Science, 1997; 52:4423-4428.
19. Schmidt, DM, George, JS, Penttila, SI, Caprihan, A and Fukushima, E, “Diffusion Imaging with Hyperpolarized 3He Gas,” J. Magn. Reson., 1997; 129:184-187.
20. Kuethe, DO, Caprihan, A, Fukushima, E and Waggoner, RA, “Imaging lungs using inert fluorinated gases,” Magn. Reson. Med., 1998; 39:85-88.
21. Brown, S, Caprihan, A, and Hardy, R. “Experimental observation of fluid flow channels in a single fracture,” J. Geophys. Res., 1998; 103: 5125-5132.
22. Gach, HM, Lowe, IJ, Madio, DP, Caprihan, A, Altobelli, SA, Kuethe, DO, and Fukushima, E, “A Programmable Pre-Emphasis System,” Magn. Reson. Med., 1998; 40:427-431.
23. Kuethe, DO, Caprihan, A, Lowe, IJ, Madio, DP and Gach, HM, “Transforming NMR DATA Despite Missing Points,” J. Magn. Reson., 1999; 139:18-25.
24. Seymour, JD, Caprihan, A, Altobelli, SA and Fukushima, E, “Pulsed Gradient Spin Echo Nuclear Magnetic Resonance Imaging of Diffusion in Granular Flow,” Phys. Rev. Lett., 2000; 84:266-269.
25. Caprihan, A and Seymour, JD, "Correlation Time and Diffusion Coefficient Imaging: Application to a Granular Flow System." J. Magn. Res., 2000; 144:96-107.
26. Kuethe, DO, Caprihan, A, Gach, HM, Lowe, IJ, and Fukushima, E, “Imaging Obstructed Ventilation with NMR using Inert Fluorinated Gases” J. Appl. Physiol., 2000; 88:2279-2286.
27. Caprihan, A, Clewett, CFM, Kuethe, DO, Fukushima, E and Glass, SJ, “Characterization of partially sintered ceramic powder compacts using fluorinated gas NMR imaging” Magn. Reson. Imag., 2001; 19:311-317.
28. Beyea SD, Caprihan, A, Clewett, CFM and Glass, SJ “Spatially Resolved Adsorption Isotherms of Thermally Polarized Perfluorinated Gases in Yttria-Stabilized Tetragonal-Zirconia Polycrystal Ceramic Materials with NMR Imaging.” Appl. Magn. Reson. 2002 22:175-186.
29. Beyea SD, Caprihan, A, Glass, SJ and DiGiovanni, A, “Nondestructive characterization of nanopore microstructure: Spatially Resolved Brunauer-Emett_Teller Isotherms using nuclear magnetic resonance Imaging.” J. of Appl. Phys. 2003 94:935-941.
30. Loeppky, JA, Caprihan, A, Altobelli, SA, Icenogle, MV, Scotto, P, Vidal Melo, MF. Validation of a two-compartment model of ventilation/perfusion distribution. Respir. Physiol. Neurobiol. 2006 151:74-92.
31. Flemming, L, Wang, Y, Caprihan, A, Eiselt, M, Haueisen, J, Okada, Y, “Evaluation of the distortion of EEG signals caused by a hole in the skull mimicking the fontanel in the skull of human neonates.” Clin. Neurophysiol. 2005 116:1142-1152.
32. Beyea, SD, Kuethe, DO, McDowell, AF, Caprihan, A and Glass, SJ, “NMR Imaging of Functionalized Ceramics” in NMR Imaging in Chemical Engineering S. Stapf and S.-I Han, Ed (Weinheim, Germany, Wiley-VCH: 2005).
33. Gasparovic, C, Song, T, Devier, D, Bockholt, HJ, Caprihan, A, Mullins, PG, Posse, S, Jung, RE, Morrison, LA. “Use of tissue water as a concentration reference for proton spectroscopic imaging.” Magn. Reson. Med. 2006 55:1219-1226.
34. Loeppky, JA, Icenogle, MV, Caprihan, A, Vidal Melo, MF, Altobelli, SA, “CO2 rebreathing model in COPD: blood-to-gas equilibrium.” Eur. J. Appl. Physiol. 2006 98:450-60.
35. Philips, JA, Sullivan, KJ, Burtner, PA, Caprihan, A, Provost, B, and Bernitsky-Beddingfield, A. “Ankle Dorsiflexion fMRI in children with cerebral palsy undergoing intensive body-weight-support treadmill training: a pilot study.” Developmental Medicine and Child Neurology. 2007 49:39-44.
36. Sanfratello, L, Caprihan, A, and Fukushima, E. Velocity depth profile of granular matter in horizontal rotating drum. Granular matter. Granular Matter 2007 9:1-6.
37. Lin, F-H, Tsai, S-Y, Otazo, R, Caprihan, A, Wald, LL, Belliveau, JW, and Posse, S. “Sensitivity-encoded (SENSE) proton echo planar spectroscopic imaging (PEPSI) in human brain.” Magn. Reson. Med. 2007 57:249-257.
38. Wakana S, Caprihan A, Panzenboeck M, Perry M, Fallon J, Gollub RL, Hua K, Zhang J, Jiang H,, Dubey P, Blitz A, van Zijl PCM, and Mori S. “Tractography-based quantitative analysis of white matter tractography: Tracking protocol, reproducibility and tract-specific quantification of cerebral hemisphere.” Neuroimage 2007 36(3):630-644. PMCID: PMC2350213
39. Caprihan A, Pearlson GD, Calhoun VD. Application of principal component analysis to distinguish patients with schizophrenia from healthy controls based on fractional anisotropy measurements. Neuroimage. 2008 42(2) 675-682. PMCID: PMC2566788
40. Michael AM, Calhoun VD, Pearlson GD, Baum SA, Caprihan A. Correlations of diffusion tensor imaging values and symptom scores in patients with schizophrenia. Conf Proc IEEE Eng Med Biol. Soc. 2008; 5494-7. [PubMed - as supplied by publisher].
41. Mullins PG, Chen H. Xu J, Caprihan A, Gasparovic C. “Comparative reliability of proton spectroscopy techniques designed to improve detection of J-coupled metabolites.” Magn Reson Med. 2008 60(4): 964-9.
42. Jung RE, Gasparovic C, Chavez RS, Flores RA, Smith SM, Caprihan A, Yeo RA. Biochemical support for the "threshold" theory of creativity: a magnetic resonance spectroscopy study. J Neurosci 2009 29: 5319-5325. PMCID: PMC2755552
43. Feng Z, Caprihan A, Blagoev KB, Calhoun VD. Biophysical modeling of phase changes in BOLD fMRI. Neuroimage 2009 47: 540-548. PMC In Process
Research Support
Ongoing Research Support
5R01EB006841 (PI: Calhoun) 02/01/2008 - 01/31/2011
Multivariate methods for identifying multi-task/multimodal brain imaging biomarkers (NIH/NIBIB)
The goal of this project is to develop multivariate methods based upon independent component analysis to enable research on healthy versus diseased brain by identifying associations between different data types.
Role: Develop methods for multi-modal MRI data fusion
1R21AA017313 (PI: Thoma) 09/30/2007 - 08/31/2010
Adolescent Neurodevelopment and Alcohol (NIH)
The goal of this project is to directly investigate the effect of adolescent alcohol abuse on brain development. Assist with data collection, development of publications, oversee data analysis, assist with training of graduate assistants and facilitate recruitment of study subjects.
Role: Develop and analyze diffusion tensor imaging data to study adolescent alcohol abuse
1R01AG029495 (PI: Aine) 09/01/2009 - 08/31/2010
Imaging the Development of Memory Strategies in Aging (NIH/National Institute on Aging)
The goal of the project is that Dr. Julia Stephen will primarily be responsible for training the postdoctoral fellow in all aspects of the study including data acquisition, analysis, and presentation of results. She will primarily focus on training the postdoc in using CSST and cross-correlational analysis for analyzing the data. Dr. Stephen will also be involved in interpretation and writing up the results. She will also oversee the MRN subaward to ensure all pieces are accomplished.
Role: Develop and analyze diffusion tensor imaging data to study aging
Grant ID # 12456 (PI: Jung) 07/15/2007 – 07/14/2010
The Neuroscience of Creativity (The John Templeton Foundation)
This is a neuroscientific research project that attempts to link discrete brain regions and modes of neuronal operation to the construct of creativity.
Role: Develop and analyze diffusion tensor imaging data to study its relationship to creativity
Delle Foundation Donation (PI: Caprihan) 02/13/2009 – 02/12/2010
Development and Neuroanatomy in Young Children: A Longitudinal Analysis (Private Donation)
The goal of this project is to establish normal pattern of regional brain development in infants and toddlers and to understand the relationship between neuroimaging, basic environmental factors and developmental skill acquisition, focusing on early working memory.
Role: Principal Investigator
3R01MH081969 (PI: Stevens) 09/30/2009 – 09/29/2010
Adolescent Maturation of Brain Network Integration for Executive Control Abilities (NIH/NIMH)
The main goal is designing the diffusion tensor imaging MRI experiment and writing software for its analysis. Collaborate with Dr. Stevens in data interpretation and preparation of research publications.
Role: Co-Investigator
PO984339 (PI: Mayer) 12/15/2009 – 09/30/2010
Real-Time Neuronal Current Imaging of the Human Brain to Improve Understanding of Decision Making (Sandia National Laboratory)
Collaborate with SNL and UNM to detect neuronal responses during perceptual decision making by investigating the effects of synchronously firing cortical neurons (and their associated magnetic fields) on the water proton signal.
Role: Co-Investigator
Completed Research Support
PO 883164 (PI: Calhoun) 06/01/2009 - 09/30/2009
Mitigation Strategies for Traumatic Brain Injury (TBI) (Sandia National Laboratory)
The scopes of this project are to assist with the computerized analysis of DTI parameters. This will include regional assignment for comparisons to simulation predictions. Also, to assist in the analysis of cluster peak locations of regions of change in DTI parameters to regions of predicted stress, energy, and/or power deposition as predicted by the simulation studies performed at SNL.
Role: MRI physicist
DE-FG02-08ER64581 (PI: Rasure) 04/01/2008 - 09/30/2009
Research and Development of Better Diagnostic Tools for Mental Illness, Neurological Disorders, Traumatic Brain Injury and Post-Traumatic Stress Disorder (DOE)
This grant consists of various projects for Research and Development of Better Diagnostic Tools for Mental Illness, Neurological Disorders, Traumatic Brain Injury and Post-Traumatic Stress Disorder.
Role: MRI physicist
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