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Assistant Professor of Translational Neuroscience
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 Dr. Weisend investigates the neurophysiology of normal memory and cognitive dysfunction and has done clinical and research work on epilepsy, using magnetoencephalography (MEG) to localize the exact areas of the brain where the epilepsy originates.
He is one of only a few experts in the nation able to identify and so specifically define the location of epileptic seizures to allow for the most challenging and precise surgeries to alleviate the symptoms.
Education
• B.S., Biology & Psychology, Heidelberg College
• M.S., Behavioral Neuroscience, University of New Mexico
• Ph.D., Behavioral Neuroscience, University of New Mexico
Positions
• July 1996 - December 2004: Research Scientist, Center for Functional Brain Imaging, New Mexico VA Health Care System, Albuquerque, NM
• January 1997 - present: Clinical Assistant Professor, Department of Radiology, University of New Mexico Health Sciences Center, Albuquerque, NM
• January 2000 - present: Research Assistant Professor, Department of Psychology, University of New Mexico, Albuquerque, NM
• January 2005 - present: Research Scientist, Mind Research Network, Albuquerque, NM
Honors
• 1994 National Science Foundation Travel Award for the NATO Advanced Study Institute on Behavioral
Brain Research in Naturalistic and Seminaturalistic Settings, Aquafredda di Maratea, Italy
• 1994 NATO Travel Fellowship for the NATO Advanced Study Institute on Behavioural Brain Research in
Naturalistic and Seminaturalistic Settings, Maratea, Italy
• 1995 Benjamin Franklin Haught Memorial Scholarship, University of New Mexico
• 1995 Scientific Secretariat Scholarship for the First French-American Summer School on
Neurobehavioral Genetics, Paris, France
• 1996 Program Committee Travel Award for the First French-American Summer School on
Neurobehavioral Genetics, Paris, France
• 1996 Student Travel Award, International Behavioral Neuroscience Society, Cancun, Quintana Roo, Mexico
• 1997 Graduate Research Project and Travel Grant, University of New Mexico
• 1997 Haught Memorial Dissertation Research Award, University of New Mexico
Selected Peer-Reviewed Publications
1. Feeney, D.M., Weisend, M.P., Kline, A.E. (1993). "Noradrenergic pharmacotherapy, intracerebral infusion and adrenal transplantation promote functional recovery after cortical damage." J Neural Transplant Plast 4(3): 199-213. PMCID: PMC2565261
2. Weisend, M. P. and Feeney, D.M. (1994). "The relationship between traumatic brain injury-induced changes in brain temperature and behavioral and anatomical outcome." J Neurosurg 80(1): 120-32.
3. Day, LB., Weisend, M., Sutherland, R.J., Schallert, T. (1999). "The hippocampus is not necessary for a place response but may be necessary for pliancy." Behav Neurosci 113(5): 914-24.
4. Lewine, J.D., Andrews, R., Chez, M., Patil, A.A., Devinsky, O., Smith, M., Kanner, A., Davis, J.T., Funke, M., Jones, G., Chong, B., Provencal, S., Weisend, M., Lee, R.R, Orrison, W.W., Jr. (1999). "Magnetoencephalographic patterns of epileptiform activity in children with regressive autism spectrum disorders." Pediatrics 104(3 Pt 1): 405-18.
5. Mumby, D.G., Astur, R.S., Weisend, M.P., Sutherland, R.J. (1999). "Retrograde amnesia and selective damage to the hippocampal formation: memory for places and object discriminations." Behav Brain Res 106(1-2): 97-107.
6. Huang, M.X., Aine, C., Davis, L., Butman, J., Christner, R., Weisend, M.P., Stephen, J., Meyer, J., Silveri, J., Herman, M., Lee, R.R. (2000). "Sources on the anterior and posterior banks of the central sulcus identified from magnetic somatosensory evoked responses using multistart spatio-temporal localization." Hum Brain Mapp 11(2): 59-76.
7. Shih, J J., Weisend, M.P., Davis, J.T., Huang, M. (2000). "Magnetoencephalographic characterization of sleep spindles in humans." J Clin Neurophysiol 17(2): 224-31.
8. Sutherland, R , Weisend, M.P., Mumby, D., Astur, R.S., Hanlon, F.M., Koerner, A., Thomas, M.J., Wu, Y., Moses, S.N., Cole, C., Hamilton, D.A., Hoesing, J.M.. (2001). "Retrograde amnesia after hippocampal damage: recent vs. remote memories in two tasks." Hippocampus 11(1): 27-42.
9. Edgar, J.C., Huang, M.X., Weisend, M.P., Sherwood, A., Miller, G.A., Adler, L.E., CaÒive, J.M. (2003). "Interpreting abnormality: an EEG and MEG study of P50 and the auditory paired-stimulus paradigm." Biol Psychol 65(1): 1-20.
10. Hanlon, F.M., Weisend, M.P., Huang, M., Lee, R.R., Moses, S.N., Paulson, K.M., Thoma, R.J., Miller, G.A., CaÒive, J.M. (2003). "A non-invasive method for observing hippocampal function." Neuroreport 14(15): 1957-60.
11. Huang, M.X., Edgar, J.C., Thoma, R.J., Hanlon, F.M., Moses, S.N., Lee, R.R., Paulson, K.M., Weisend, M.P., Irwin, J.G., Bustillo, J.R., Adler, L.E., Miller, G.A., CaÒive, J.M.. (2003). "Predicting EEG responses using MEG sources in superior temporal gyrus reveals source asynchrony in patients with schizophrenia." Clin Neurophysiol 114(5): 835-50.
12. Lewis, S., Thoma, R.J., Lanoue, M.D., Miller, G.A., Heller, W., Edgar, C., Huang, M., Weisend, M.P., Irwin, J., Paulson, K., CaÒive, J.M. (2003). "Visual processing of facial affect." Neuroreport 14(14): 1841-5.
13. Thoma, R J., Hanlon, F.M., Moses, S.N., Edgar, J.C., Huang, M., Weisend, M.P., Irwin, J., Sherwood, A., Paulson, K., Bustillo, J., Adler, L.E., Miller, G.A., CaÒive, J.M. (2003). "Lateralization of auditory sensory gating and neuropsychological dysfunction in schizophrenia." Am J Psychiatry 160(9): 1595-605.
14. Huang, M., Davis, L.E., Aine, C., Weisend, M. Harrington, D., Christner, R., Stephen, J., Edgar, J.C., Herman, M., Meyer, J., Paulson, K., Martin, K., Lee, R.R., (2004). "MEG response to median nerve stimulation correlates with recovery of sensory and motor function after stroke." Clin Neurophysiol 115(4): 820-33.
15. Huang, M.X., Harrington, D.L., Paulson, K.M., Weisend, M.P., Lee, R.R. (2004). "Temporal dynamics of ipsilateral and contralateral motor activity during voluntary finger movement." Hum Brain Mapp 23(1): 26-39.
16. Huang, M.X., Shih, J.J., Lee, R.R., Harrington, D.L., Thoma, R.J., Weisend, M.P., Hanlon, F., Paulson, K.M., Li, T., Martin, K., Millers, G.A., CaÒive, J.M. (2004). "Commonalities and differences among vectorized beamformers in electromagnetic source imaging." Brain Topogr 16(3): 139-58.
17. Shih, J.J., Weisend, M.P., Lewine, J., Sanders, J., Dermon, J., Lee, R. (2004). "Areas of interictal spiking are associated with metabolic dysfunction in MRI-negative temporal lobe epilepsy." Epilepsia 45(3): 223-9.
18. Thoma, R.J., Hanlon, F.M., Sanchez, N., Weisend, M.P., Huang, M., Jones, A. Miller, G.A., CaÒive, J.M. (2004). "Auditory sensory gating deficit and cortical thickness in schizophrenia." Neurol Clin Neurophysiol 2004: 62.
19. Edgar, J.C., Miller, G.A., Moses, S.N., Thoma, R.J., Huang, M.X., Hanlon, F.M., Weisend, M.P., Sherwood, A., Bustillo, J., Adler, L.E., CaÒive, J.M.. (2005). "Cross-modal generality of the gating deficit." Psychophysiology 42(3): 318-27.
20. Hanlon, F.M., Miller, G.A., Thoma, R.J., Irwin, J., Jones, A., Moses, S.N., Huang, M., Weisend, M.P., Paulson, K.M., Edgar, J.C., Adler, L.E., CaÒive, J.M. (2005). "Distinct M50 and M100 auditory gating deficits in schizophrenia." Psychophysiology 42(4): 417-27.
21. Hanlon, F. M., Weisend, M.P., Yeo, R.A., Huang, M., Lee, R.R., Thoma, R.J., Moses, S.N., Paulson, K.M., Miller, G.A., CaÒive, J.M. (2005). "A specific test of hippocampal deficit in schizophrenia." Behav Neurosci 119(4): 863-75.
22. Huang, M. X., Lee, R.R., Miller, G.A., Thoma, R.J., Hanlon, F.M., Paulson, K.M., Martin, K., Harrington, D.L., Weisend, M.P., Edgar, J.C., CaÒive, J.M.. (2005). "A parietal-frontal network studied by somatosensory oddball MEG responses, and its cross-modal consistency." Neuroimage 28(1): 99-114.
23. Stephen, J.M., Ranken, D.M., Aine, C.J., Weisend, M.P., Shih, J.J. (2005). "Differentiability of simulated MEG hippocampal, medial temporal and neocortical temporal epileptic spike activity." J Clin Neurophysiol 22(6): 388-401.
24. Thoma, R J., Hanlon, F.M., Moses, S.N., Ricker, D., Huang, M., Edgar, C., Irwin, J., Torres, F., Weisend, M.P., Adler, L.E., Miller, G.A., CaÒive, J.M. (2005). "M50 sensory gating predicts negative symptoms in schizophrenia." Schizophr Res 73(2-3): 311-8.
25. Canive, J.M., G.A. Miller, Irwin, J.G., Moses, S.N., Thoma, R.J., Edgar, J.C., Sherwood, A., Torres, F., Lanoue, M., Lewis, S., Hanlon, F.M., Weisend, M.P., Mead, V., Tuason, V.B. (2006). "Efficacy of olanzapine and risperidone in schizophrenia: a randomized double-blind crossover design." Psychopharmacol Bull 39(1): 105-16.
26. Hanlon, F.M., Weisend, M.P., Hamilton, D.A., Jones, A.P., Thoma, R.J., Huang, M., Martin, K., Yeo, R.A., Miller, G.A., CaÒive, J.M. (2006). "Impairment on the hippocampal-dependent virtual Morris water task in schizophrenia." Schizophr Res 87(1-3): 67-80.
27. Thoma, R.J., Hanlon, F.M., Miller, G.A., Huang, M., Weisend, M.P., Sanchez, F.P., Waldorf, V.A., Jones, A., Smith, A., Formoso, M.J., CaÒive, J.M. (2006). "Neuropsychological and sensory gating deficits related to remote alcohol abuse history in schizophrenia." J Int Neuropsychol Soc 12(1): 34-44.
28. Hamilton, D.A., Akers, K.G., Weisend, M.P., Sutherland, R.J. (2007). "How do room and apparatus cues control navigation in the Morris water task? Evidence for distinct contributions to a movement vector." J Exp Psychol Anim Behav Process, 33(2): 100-14.
29. M.P. Weisend, F.M. Hanlon, R. MontaÒo, S.P. Ahlfors, A.C. Leuthold, D. Patazis, J.C. Mosher, A.P. Georgopoulos, M.S. H‰m‰l‰inen, and C.J. Aine. (2007). "Paving the way for cross-site pooling of magnetoencephalography (MEG) data." International Congress Series 1300: 615-618.
30. Moses, S.N., Houck, J.M., Martin, T., Hanlon, F.M., Rayan, J.D., Thoma, R.J., Weisend, M.P., Jackson, E.M., Pekkonen E., Tesche, C.D. (2007). "Dynamic neural activity recorded from human amygdala during fear conditioning using magnetoencephalography." Brain Res Bull 71(5): 452-60.
31. Thoma, R.J., Hanlon, F.M., Huang, M., Miller, G.A., Moses, S.N., Weisend, M.P., Jones, A., Paulson, K.M., Irwin, J., CaÒive, J.M. (2007). "Impaired secondary somatosensory gating in patients with schizophrenia." Psychiatry Res 151(3): 189-99.
32. Thoma RJ, Hanlon FM, Petropoulos H, Miller GA, Moses SN, Smith A, Parks L, Lundy SL, Sanchez NM, Jones A, Huang M, Weisend MP, CaÒive JM. Schizophrenia diagnosis and anterior hippocampal volume make separate contributions to sensory gating. Psychophysiology. (2008) Nov; 45(6):926-35.
33. Hamilton, D.A., Akers, K.G., Johnson, T.E., Rice, J.P., Candelaria, F.T., Sutherland, R.J., Weisend, M.P., Redhead, E.S. (2008). "The relative influence of place and direction in the Morris water task." J Exp Psychol Anim Behav Process, 34(1): 31-53.
34. Edgar, JC, Hanlon, FM, Huang, MX, Weisend, MP, Thoma, RJ, Carpenter, B, Hoechstetter, K, Canive, JM, Miller, GA. (2008). ìSuperior temporal gyrus spectral abnormalities in schizophrenia,î Psychophysiology, 45(5):812-24. PMCID: PMC2685182
35. Thoma, R. J., F. M. Hanlon, et al. (2008). "Schizophrenia diagnosis and anterior hippocampal volume make separate contributions to sensory gating." Psychophysiology 45(6): 926-35.
36. Shih, J.J. and Weisend M.P. Magnetoencephalography in Epilepsy in Epilepsy: Mechanisms, Models, and Translational Perspectives edited by J.M. Rho, R. Sankar, and C.E. Strafstrom.(2009) (in press).
Research Support
Ongoing Research Support
NBCHC070103 (PI: Weisend) 4/1/2007 – 2/28/2011
Accelerated Learning: Brain Stimulation for Enhanced Threat Detection (DARPA)
Development of quantitative and integrative neuroscience-based approaches for measuring, tracking and accelerating learning of threat detection, decision-making, and accurate response in warfighters through use of virtual reality environments, multimodal brain imaging techniques, novel methods for detection and analysis of non-linear brain networks, and direct brain stimulation to enhance attention.
Role: PI
1R21 MH080141-01A1 (PI: Aine) 12/1/2007-11/30/2010
Realistic Simulations and Empirical Data: MEG Reconstructions of Time (NIH/NIMH)
This project will test versions of the most popular MEG source reconstruction algorithms using realistic simulations and real data collected on the same subjects on each of the three major MEG machines to determine the source localization accuracy and more importantly the ability of these algorithms to properly model the timing of the activity. It is designed to help provide a comprehensive test of MEG algorithms as well as test data sets that can be used to test new algorithms in hopes of allowing MEG investigators to better understand the strengths and weaknesses of the various algorithms currently available.
Role: Co-Investigator
SNA07-0401 LDRD (PI: Schwindt) 2/1/2009-9/30/2011
Atomic magnetometer for human magnetoencephalography (Subcontract: Sandia National Laboratories)
In magnetoencephalography (MEG) the magnetic fields produced by neural currents in the brain are measured. Being on of the few non-invasive techniques for measuring brain activity with high temporal fidelity that also allows spatial localization of neural activity, MEG is a critical tool for furthering our understanding of brain function and the physiology underlying human cognitive processes. Low-temperature superconducting quantum interference devices (SQUIDs) have long been the only sensors capable of making high quality MEG measurements. Although SQUIDs have been and invaluable research tool for MEG, they do have significant limitations. The largest is that they require cryogenic cooling (liquid helium). This leads to device of considerable size, and the constraint of an available source of liquid helium, limiting the possibility of eventual miniaturization and portability. We propose build a magnetometer based on the spin precession of alkali atoms for MEG applications.
Role: Co-Investigator
SNL PO# 998724 (PI: Weisend) 2/10/2010 – 2/9/2010
Atomic Magnetometer for Human Magnetoencephalograpy (Sandia National Laboratories)
Assist with MEG usage and data analysis, evaluate need for FDA IDE exemption, prepare FDA IDE if necessary, obtain IRB renewal.
Role: Principal Investigator
Completed Research Support
DE-FG-02-08ER64581 (PI: Weisend) 4/1/2006-7/30/2009
MEG/EEG Program Administration (DOE/MIND Research Network)
This project involves the administration of the MEG/EEG program including Users Group Meetings, the supervision of technical staff, troubleshooting the system, and organizing the overall effort.
Role: PI
No Number (PI: Weisend) 1/1/2008-9/30/2009
Fundamental Mechanisms of Neural Plasticity in Visual Cortex (MRN Internal Funding)
This project examines the test/retest reliability of visual responses as a function of stimulus repetition. This project uses the existing MIND MEG consortium and DARPA datasets to evaluate the hypothesis that changes in the response of the brain to repeated stimuli is the result of plastic change in the synaptic potentials giving rise to the visual response.
Role: PI
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