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Scientific Lectures //

Individual Differences in Resting-State Functional Connectivity: Challenges and Applications

Rasmus Birn, Ph.D.- Assistant Professor, University of Wisconsin-Madison

Presented: August 28, 2015

ABSTRACT: The use of magnetic resonance imaging (MRI) to measure functional connections in the brain while the subject is “at rest” (“resting-state functional connectivity”) has increased dramatically in the past decade. Advances are being made in the acquisition and processing of this data, and this technique is being applied to the study of a wide range of both typical and atypical brain function. The ultimate clinical utility of this technique, however, requires the ability to measure robust and reliable differences in functional connectivity in individual subjects, and in this endeavor many challenges remain. Resting-state functional connectivity, for example, is sensitive to many sources of noise. In this talk, I will discuss recent estimates of the test-retest reliability of resting-state functional connectivity, current methods to reduce various sources of noise, and some promising applications showing that we can capture.

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