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Professor of Translational Neuroscience
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The goal of this project is to elucidate gene X environment interactions in the development of marijuana abuse and dependence. I have extensive experience and expertise in methodological, quantitative, and statistical approaches, particularly with meditational models. I routinely utilize high level statistical tests in my work including interactions in multiple regression (Bryan, 2001; Robbins & Bryan, 2004), structural equation modeling (e.g., Bryan et al., 1996; Bryan et. al 2000; Bryan et al., 2004), and various forms of multilevel and longitudinal modeling (e.g., Bryan et al., 2006) and can both conduct these analyses myself as well as train and supervise others to do so. With funding from NIAAA and NIDA, I also have experience in the design, implementation, completion, analysis and interpretation of research projects involving substance use among adolescents and young adults. Thus, my methodological and substantive expertise are well-suited to the project, and I anticipate being actively involved in methodological and design issues, supervising the conduct of statistical analyses, and of course publishing the results of the study.
Education
• B.A., Psychology, University of California, Los Angeles
• M.A., Social Psychology, Quantitative Emphasis, Arizona State University
• Ph.D., Social Psychology, Quantitative Emphasis, Arizona State University
Positions
• 1996-1997 Graduate Teaching Assistant, Graduate Statistics Series in ANOVA and Regression, Arizona State University
• 1997-1997 Instructor, Introductory Statistics, Arizona State University
• 1997-1998 Research Associate, Department of Psychology, University of Connecticut, Center for HIV Intervention and Prevention
• 1998-1999 Research Assistant Professor, Department of Psychology. University of Connecticut, Center for HIV Intervention and Prevention
• 1999-2004 Faculty Research Associate, Institute of Behavioral Science, University of Colorado at Boulder.
• 1999-2006 Assistant Professor, Department of Psychology, University of Colorado at Boulder.
• 2006-2007 Associate Professor with tenure, Department of Psychology, University of Colorado at Boulder.
• 2007-present Associate Professor with tenure to Professor with tenure, Department of Psychology, Faculty Associate, Center for Alcoholism, Substance Abuse and Addictions (CASAA); University of New Mexico; Professor of Translational Neuroscience, Mind Research Network (MRN)
Selected Other Experience and Professional Memberships
• 1997-present Member, American Psychological Association, Affiliated with Divisions 38 (Health Psychology), 5 (Statistics), and 8 (Social Psychology).
• 1997-present Ad hoc reviewer for- Health Psychology; Psychological Methods; J Consulting/Clinical Psychology; Social Science and Medicine; Annuals of Behavioral Medicine; many others
• 2000-2005 Editorial Board, Health Psychology
• 2000-present Member, Research Society on Alcoholism
• 2004-2008 Member, National Institutes of Health, Behavioral and Social Science Approaches to Preventing HIV/AIDS (BSPH) study section
• 2007-present Associate Editor, AIDS and Behavior
• 2007-present Member, Society for Prevention Research
• 2008-present Member, Society for Behavioral Medicine
Honors
• 1993-1996 National Science Foundation Graduate Fellowship
• 2000 Bruce K. Ekstrand Junior Faculty Development Award
• 2002 Building Community CU@Lunch Mentor Appreciation Award
• 2005 University of Colorado Department of Psychology Faculty Research Award
• 2006 American Psychological Association (APA) Distinguished Scientific Award for Early Career Contribution to Psychology in the area of Health Psychology
• 2006 University of Colorado Department of Psychology Faculty Teaching Award
Selected Peer-Reviewed Publications (selected from over 65):
1. Bryan AD, Aiken LS and West SG. Increasing condom use: Evaluation of a theory-based intervention to decrease sexually transmitted disease in women. Health Psychology 1996; 15:371-382.
2. Hutchison KE, McGeary J, Smolen A, Bryan A and Swift RM. The DRD4 VNTR polymorphism moderates craving after alcohol consumption. Health Psychology 2002; 21:139-146.
3. Hutchison MC, Stallings MC McGeary J and Bryan A. Population stratification in the genetic case control design: Fatal threat or red herring? Psychological Bulletin 2004; 130:66–79.
4. Helstrom A, Bryan A, Hutchison KE, Riggs P and Blechman E. Tobacco and alcohol use as an explanation for the association between externalizing behavior and illicit drug use among delinquent adolescents. Prevention Science 2004; 5:267-277.
5. Bryan A, Rocheleau CA, Robbins RN and Hutchison KE. Condom use among high-risk adolescents: Testing the influence of alcohol use on the relationship of cognitive correlates of behavior. Health Psychology 2005; 24:133-142. PMCID: PMC1199528
6. Ray LA, Hutchison KE and Bryan A. Psychosocial predictors of treatment outcome, dropout, and change processes in a pharmacological clinical trial for alcohol dependence. Addictive Disorders & Their Treatment 2006; 5:179-190.
7. Helstrom A, Hutchison KE and Bryan A. Motivational enhancement therapy for high-risk adolescent smokers. Addict Behav 2007; 32(10):2404-10. PMCID: PMC2082126
8. Hutchison DA, Allen DL, Filbey FM, Jepson C, Leman C, Benowitz NL, Stitzel J, Bryan A, McGeary J and Haughey HM. CHRNA4 and tobacco dependence: From gene regulation to treatment outcome. Arch Gen Psychiatry 2007; 64(9):1078-86.
9. Bryan A, Schmiege SJ and Broaddus MR. Mediational analysis in HIV/AIDS research: estimating multivariate path analytic models in a structural equation modeling framework. AIDS Behavior 2007; 11(3):365-83.
10. Bryan A, Ray L and Cooper ML. Alcohol use and protective sexual behaviors among high-risk adolescents. J Stud on Alcohol Drugs 2007; 68(3):327-35.
11. Ray LA, Bryan A, Mackillop J, McGeary J, Hesterberg K, Hutchison KE. The dopamine D(4) Receptor (DRD4) gene exon III polymorphism, problematic alcohol use and novelty seeking: direct and mediated genetic effects. Addit Biol 2008; Aug 19 [Epub ahead of print]
12. Schmiege SJ, Broaddus MR, Levin M and Bryan, A. HIV/STD risk reduction RCT: Mechanisms of change underlying psychosocial and group-MET approaches. J Consulting and Clinical Psychology 2009; 77: 38-50.
13. LaChance, H., Feldstein Ewing, Sarah W., Bryan, A.D., & Hutchison, K.E. (in press) What Makes group MET work? A randomized controlled trial of college student drinkers in mandated alcohol diversion. Psychology of Addictive Behaviors.
Research Support
Ongoing Research Support
U19 AI084081-01 (Wheeler) 9/14/2009 – 9/13/2014
University of New Mexico Interdisciplinary HPV Prevention Center (NIAID)
The major goal of the Center is to establish the University of New Mexico Interdisciplinary HPV Prevention Center that incorporates interdisciplinary research approaches to address gaps in HPV prevention knowledge. Role: Biostatistician, Biostatistics Core (Core PI: Stidley)
RO1DA025074-01A2 (Hutchison) 9/1/2009-8/31/2014
Effectiveness of Varenicline: Testing Individual Differences (NIDA)
This research is designed to identify specific genetic variations that are related to how people respond to tobacco and identify how they are related to tobacco dependence. Role: Co-I
1R01 AA017878-01 (Feldstein Ewing) 8/25/2009 – 8/24/2014
AMICA: Assessing the fit of Motivational Interviewing by Cultures with Adolescents (NIAAA)
This research is designed to evaluate the efficacy of a brief intervention, motivational interviewing (MI), with Hispanic adolescents, and identify potential culturally-specific mediators and contributing genetic factors in problem drinking outcomes following this brief intervention. Role: Co-I
1 R01DA018575-01A2 (Woodall) 08/15/2009-07/31/2011
Web-based Substance Abuse and STD/HIV Prevention (NIDA)
The goal of the project is to adapt successful sexual risk behavior prevention and substance abuse prevention curricula to a Web-based interactive multi-media format, and then implement and evaluate the new curriculum in a cluster-randomized trial among adolescents in public schools. Role: Co-I
2R01AA013844-05A1 (Bryan) 7/1/2009 – 6/30/2014
Alcohol, Marijuana, and Risky Sex: Group Interventions with Detained Adolescents (NIAAA)
This research is designed to implement and carefully evaluate new intervention technologies that have the goal of decreasing alcohol- and marijuana-related sexual risk behavior in this population of highly vulnerable young people. Role: PI
RO1 DA024002 Ito (PI) 5/1/2009 – 4/30/2014
Multilevel Analysis of Self-Regulation in Substance Abuse (NIDA)
This project seeks to examine genetic, neurobiological, and social/behavioral determinants of executive function, and how these predict marijuana use among adolescents. The causal role of these variables will be examined longitudinally, by measuring each set of variables in each of three years. Role: Co-I
R01 AA017390-01 Bryan (PI) 10/1/2007 – 9/30/2012
HIV prevention with adolescents: Neurocognitive deficits and treatment response (NIAAA)
This research is designed to understand the genetic and neurocognitive predispositions that contribute to sexual risk behaviors that place criminally-involved adolescents at high risk of unintended pregnancy and STDs including HIV/AIDS. The findings will help us to design better interventions to decrease alcohol-related sexual risk behavior in this population of highly vulnerable young people. Role: PI
1 RO1 AA Hutchison (PI) 10/1/2007 – 9/30/2012
Sensitivity to Intravenous Ethanol: Genetic Determinants (NIAAA)
This study will examine the effects of a functional SNP (A118G) in the OPRM1 gene and how it influences the subjective effects of an acute infusion of alcohol, in alcohol dependent individuals compared to healthy non-dependent drinkers. Role: Co-I
R01 AA014886 Hutchison (PI) 12/1/2005-11/30/2010
A New Pharmacotherapy for Alcohol Dependence: Olanzapine (NIAAA)
The goal of this research is to test the effectiveness of Olanzapine as a treatment for alcoholics via its promise at blunting cue-elicited craving for alcohol. The project also examines moderating effects of genetic factors on medication efficacy. Role: Co-I
Completed Research Support
RO1 DA019139-01 Bryan (PI) 8/1/2004 – 7/31/2009
Marijuana Use, Gender, and Adolescent HIV Sexual Risk (NIDA)
The goal of this research is to increase understanding of the relationship of marijuana use to risky sexual behavior among highly vulnerable youth aged 14-17 years, who are using or are at high-risk for using marijuana, and who are vulnerable to sexually transmitted diseases including HIV. In addition, the research will examine the role of gender in sexual risk behaviors and the potential moderating role of gender in the marijuana/risky sex connection.
R01 CA109858-01 Bryan (PI) 7/1/2004-6/31/2009
Mediators & Moderators of Exercise Behavior Change (NCI)
The objective of the proposed research is to understand the mediators and moderators of a well-tested individually tailored, print-based intervention to increase exercise behavior among sedentary adults. Mediators and moderators to be tested include those from psychological (e.g., self-efficacy, mood), physiological (e.g., temperature and stress regulation), and genetic (e.g., BDNF, OPRM1) domains. |
